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The critical importance of epigenetics in autoimmune-related skin diseases

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 43-57 doi: 10.1007/s11684-022-0980-8

Abstract: The most important epigenetic mechanisms are DNA methylation, histone modification, and noncoding RNAs

Keywords： epigenetics     autoimmune-related skin diseases     DNA methylation     histone modifications     noncoding RNAs    

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Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 231-241 doi: 10.1007/s11684-013-0253-7

Abstract: presence of epigenetic alterations, including promoter DNA hypermethylation and post-translational modificationsof histone, which profoundly affect expression of a wide repertoire of genes critical for cancer developmentassemble into polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2) to impose the histonereview, we will first recapitulate the mechanisms of two key epigenetic pathways: DNA methylation and histonemodifications.

Keywords： liver cancer     epigenetics     histone modifications     polycomb group proteins     enhancer of zeste homolog 2 (EZH2    

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Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 79-83 doi: 10.1007/s11684-014-0314-6

Abstract: mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histoneacetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine

Keywords： MOF     histone acetyltransferase     DNA damage repair     tumorigenesis     embryonic stem cells    

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The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of histone

Shixin ZHANG,Shaohua WU,Weimin TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 357-362 doi: 10.15302/J-FASE-2016125

Abstract: experimental morphological technique, the present study revealed that trichostatin A (TSA), an inhibitor of histoneThe results suggest that histone acetylation is essential for the secondary laticifer differentiation

Keywords： Hevea brasiliensis     histone acetylation     laticifer differentiation     trichostatin     vascular cambia    

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ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC MODIFICATIONS

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also playcomplex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications

Keywords： climacteric fruit ripening / phytohormones / TFs / epigenetic modifications    

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suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 79-90 doi: 10.1007/s11684-020-0783-8

Abstract: ASIV restored acetylation of histone H3 and the p65 subunit of nuclear factor-κB in the ischemic brain, suggesting inhibition of histone deacetylase (HDAC).

Keywords： astragaloside IV     brain ischemia     natural killer cells     histone deacetylase     nuclear factor-κB    

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ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC MODIFICATIONS

Yinglin JI, Mingyang XU, Aide WANG

Frontiers of Agricultural Science and Engineering   Pages 314-334 doi: 10.15302/J-FASE-2021386

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also playcomplex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications

Keywords： climacteric fruit ripening     phytohormones     TFs     epigenetic modifications    

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Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 153-157 doi: 10.1007/s11684-009-0034-5

Abstract: To clarify the effect of DNA methylation and histone deacetylase inhibitors on the expression of the

Keywords： DNA methylation inhibitor     histone deacetylase inhibitor     bile duct carcinoma     E-cadherin    

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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 289-297 doi: 10.1007/s11684-018-0667-3

Abstract: Histone supply and dosage, as well as histone variants, are the best-known regulators of chromatin dynamicsBy facilitating cell reprogramming, histone under-dosage and histone variants should also be crucialHere we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin

Keywords： cancer-testis     TH2B     TH2A     H1T     H1.0     H1F0     linker histones    

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Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract:

The coronavirus disease 2019 (COVID-19) pandemic has led to worldwide efforts to understand the biological traits of the newly identified human coronavirus (HCoV-19) virus. In this mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spike protein (S protein), 20 are completely occupied by N-glycans, predominantly of the oligomannose type. All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completely occupied, mainly by complex N-glycans. However, glycosylation did not directly contribute to the binding affinity between HCoV-19 S protein and hACE2. Additional post-translational modification (PTM) was identified, including multiple methylated sites in both proteins and multiple sites with hydroxylproline in hACE2. Refined structural models of HCoV-19 S protein and hACE2 were built by adding N-glycan and PTMs to recently published cryogenic electron microscopy structures. The PTM and glycan maps of HCoV-19 S protein and hACE2 provide additional structural details for studying the mechanisms underlying host attachment and the immune response of HCoV-19, as well as knowledge for developing desperately needed remedies and vaccines.

Keywords： N-glycosylation     COVID-19     Spike protein     hACE2     Structure    

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Title Author Date Type Operation

The critical importance of epigenetics in autoimmune-related skin diseases

Journal Article

Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins

Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong

Journal Article

Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Journal Article

The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of histone

Shixin ZHANG,Shaohua WU,Weimin TIAN

Journal Article

ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC MODIFICATIONS

Journal Article

suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Journal Article

ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC MODIFICATIONS

Yinglin JI, Mingyang XU, Aide WANG

Journal Article

Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Journal Article

Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Journal Article

Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article